Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation
Joint Authors
Kumar Tyagi, Amit
Anthwal, Amit
Rawat, D. S.
Thakur, Bandana K.
Aggarwal, Bharat B.
Rawat, M. S. M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In a search of new compounds active against cancer, synthesis of a series of C-5 curcumin analogues was carried out.
The new compounds demonstrated good cytotoxicity against chronic myeloid leukemia (KBM5) and colon cancer (HCT116) cell lines.
Further, these compounds were found to have better potential to inhibit TNF-α-induced NF-κB activation in comparison to curcumin, which show their potential to act as anti-inflammatory agents.
Some compounds were found to show higher cytotoxicity against cancer cell lines in comparison to curcumin used as standard.
American Psychological Association (APA)
Anthwal, Amit& Thakur, Bandana K.& Rawat, M. S. M.& Rawat, D. S.& Kumar Tyagi, Amit& Aggarwal, Bharat B.. 2014. Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-478502
Modern Language Association (MLA)
Anthwal, Amit…[et al.]. Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-478502
American Medical Association (AMA)
Anthwal, Amit& Thakur, Bandana K.& Rawat, M. S. M.& Rawat, D. S.& Kumar Tyagi, Amit& Aggarwal, Bharat B.. Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-478502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478502
