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The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias
Joint Authors
Gourgiotis, Dimitrios
Ardavanis, Alexandros
Tzifi, Flora
Economopoulou, Christina
Papageorgiou, Sotirios G.
Scorilas, Andreas
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The disturbance of apoptosis molecular signaling pathways is involved in carcinogenesis.
BCL2 family of proteins is the hallmark of apoptosis regulation.
In the last decade, new members of BCL2 gene family were discovered and cloned and were found to be differentially expressed in many types of cancer.
BCL2 protein family, through its role in regulation of apoptotic pathways, is possibly related to cancer pathophysiology and resistance to conventional chemotherapy.
It is well known that leukemias are haematopoietic malignancies characterized by biological diversity, varied cytogenetics, different immunophenotype profiles, and diverse outcome.
Current research focuses on the prognostic impact and specific role of these proteins in the pathogenesis of leukemias.
The understanding of the molecular pathways that participate in the biology of leukemias may lead to the design of new therapies which may improve patients' survival.
In the present paper, we describe current knowledge on the role of BCL2 apoptosis regulator proteins in acute and chronic leukemias.
American Psychological Association (APA)
Tzifi, Flora& Economopoulou, Christina& Gourgiotis, Dimitrios& Ardavanis, Alexandros& Papageorgiou, Sotirios G.& Scorilas, Andreas. 2011. The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias. Advances in Hematology،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-478517
Modern Language Association (MLA)
Tzifi, Flora…[et al.]. The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias. Advances in Hematology No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-478517
American Medical Association (AMA)
Tzifi, Flora& Economopoulou, Christina& Gourgiotis, Dimitrios& Ardavanis, Alexandros& Papageorgiou, Sotirios G.& Scorilas, Andreas. The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias. Advances in Hematology. 2011. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-478517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478517