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Efficacy, Tolerability, and Acceptability of Iron Hydroxide Polymaltose Complex versus Ferrous Sulfate : A Randomized Trial in Pediatric Patients with Iron Deficiency Anemia
Joint Authors
Agaoglu, Leyla
Yasa, Beril
Unuvar, Emin
Source
International Journal of Pediatrics
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Iron polymaltose complex (IPC) offers similar efficacy with superior tolerability to ferrous sulfate in adults, but randomized trials in children are rare.
In a prospective, open-label, 4-month study, 103 children aged >6 months with iron deficiency anemia (IDA) were randomized to IPC once daily or ferrous sulfate twice daily, (both 5 mg iron/kg/day).
Mean increases in Hb to months 1 and 4 with IPC were 1.2±0.9 g/dL and 2.3±1.3 g/dL, respectively, (both P=0.001 versus baseline) and 1.8±1.7 g/dL and 3.0±2.3 g/dL with ferrous sulfate (both P=0.001 versus baseline) (n.s.
between groups).
Gastrointestinal adverse events occurred in 26.9% and 50.9% of IPC and ferrous sulfate patients, respectively (P=0.012).
Mean acceptability score at month 4 was superior with IPC versus ferrous sulfate (1.63±0.56 versus 2.14±0.75, P=0.001).
Efficacy was comparable with IPC and ferrous sulfate over a four-month period in children with IDA, but IPC was associated with fewer gastrointestinal adverse events and better treatment acceptability.
American Psychological Association (APA)
Yasa, Beril& Agaoglu, Leyla& Unuvar, Emin. 2011. Efficacy, Tolerability, and Acceptability of Iron Hydroxide Polymaltose Complex versus Ferrous Sulfate : A Randomized Trial in Pediatric Patients with Iron Deficiency Anemia. International Journal of Pediatrics،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-478534
Modern Language Association (MLA)
Yasa, Beril…[et al.]. Efficacy, Tolerability, and Acceptability of Iron Hydroxide Polymaltose Complex versus Ferrous Sulfate : A Randomized Trial in Pediatric Patients with Iron Deficiency Anemia. International Journal of Pediatrics No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-478534
American Medical Association (AMA)
Yasa, Beril& Agaoglu, Leyla& Unuvar, Emin. Efficacy, Tolerability, and Acceptability of Iron Hydroxide Polymaltose Complex versus Ferrous Sulfate : A Randomized Trial in Pediatric Patients with Iron Deficiency Anemia. International Journal of Pediatrics. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-478534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478534