Does Type of Tumor Histology Impact Survival among Patients with Stage IIIBIV Non-Small Cell Lung Cancer Treated with First-Line Doublet Chemotherapy?

Abstract EN

Chemotherapy regimens may have differential efficacy by histology in nonsmall cell lung cancer (NSCLC).

We examined the impact of histology on survival of patients (N=2,644) with stage IIIB/IV NSCLC who received first-line cisplatin/carboplatin plus gemcitabine (C/C+G) and cisplatin/carboplatin plus a taxane (C/C+T) identified retrospectively in the SEER cancer registry (1997–2002).

Patients with squamous and nonsquamous cell carcinoma survived 8.5 months and 8.1 months, respectively (P=.018).

No statistically significant difference was observed in survival between C/C+G and C/C+T in both histologies.

Adjusting for clinical and demographic characteristics, the effect of treatment regimen on survival did not differ by histology (P for interaction =.257).

There was no statistically significant difference in hazard of death by histology in both groups.

These results contrast the predictive role of histology and improved survival outcomes observed for cisplatin-pemetrexed regimens in advanced nonsquamous NSCLC.