Effects of Hydroquinone on Cytoskeletal Organization and Intracellular Transport in Cultured Xenopus laevis Melanophores and Fibroblasts
Joint Authors
Norström, Elisabeth
Wallin, Margareta
Aspengren, Sara
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hydroquinone is used as a skin-lightening agent, it is also present in different chemical products and cigarette smoke.
It is believed to inhibit melanin production in melanocytes by inhibiting the key enzyme tyrosinase.
In the present study, we show that hydroquinone had severe effects on microtubules and actin filaments in cultured Xenopus laevis melanophores as studied by immunohistochemistry.
It affected the intracellular transport of melanosomes, induced bundling of microtubules and disassembly of actin filaments at 10 and 50 μM, and at 100 μM proper adhesion to the substrate was lost.
Effects occurred at lower concentrations than what previously has been stated to be cytotoxic, and the results show that tyrosinase is not the only cellular target.
The cytoskeleton is of utmost importance for the function of all cells and across species.
Our data has therefore to be considered in the discussions about the use of hydroquinone for bleaching of skin.
American Psychological Association (APA)
Aspengren, Sara& Norström, Elisabeth& Wallin, Margareta. 2012. Effects of Hydroquinone on Cytoskeletal Organization and Intracellular Transport in Cultured Xenopus laevis Melanophores and Fibroblasts. ISRN Cell Biology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-478571
Modern Language Association (MLA)
Aspengren, Sara…[et al.]. Effects of Hydroquinone on Cytoskeletal Organization and Intracellular Transport in Cultured Xenopus laevis Melanophores and Fibroblasts. ISRN Cell Biology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-478571
American Medical Association (AMA)
Aspengren, Sara& Norström, Elisabeth& Wallin, Margareta. Effects of Hydroquinone on Cytoskeletal Organization and Intracellular Transport in Cultured Xenopus laevis Melanophores and Fibroblasts. ISRN Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-478571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478571