The Association between Autoantibodies and Peripheral Neuropathy in Lupus Nephritis
Joint Authors
Huang, Chih-Cheng
Kung, Chia-Te
Chang, Ya-Ting
Tsai, Nai-Wen
Cheng, Ben-Chung
Lu, Cheng-Hsien
Lin, Wei-Che
Su, Yu-Jih
Huang, Chi-Ren
Chang, Wen-Neng
Su, Chih-Min
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background and Aim.
The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy in patients with systemic lupus erythematosus (SLE) and nephritis (SLE-LN) remain unsatisfactory.
This study aimed to determine the autoantibodies levels in SLE-LN patients with peripheral neuropathy.
Methods.
Data of 559 SLE-LN patients were collected retrospectively, including titers of autoantibodies, electrodiagnostic studies, and clinical manifestations.
Results.
The neurologic manifestations of the SLE-LN patients were diverse and nonspecific.
The prevalence rate of peripheral polyneuropathy was 2.68%, of which about 73.33% was mixed sensory-motor polyneuropathy.
Numbness and functional gastrointestinal problems were the most prevalent symptoms and these were noted in every subtype of peripheral neuropathy.
Among all the serology markers, anti-Ro was significantly associated with neuropathy related to SLE (P=0.009).
Conclusion.
Peripheral neuropathy among LN patients is rare and may be easily overlooked.
This study demonstrated that positive anti-Ro antibody may imply neuropathy in LN patients.
Thus, anti-Ro can be considered a biomarker that should be added to the panel of conventional autoantibodies in LN patients.
American Psychological Association (APA)
Su, Yu-Jih& Huang, Chi-Ren& Chang, Wen-Neng& Tsai, Nai-Wen& Kung, Chia-Te& Lin, Wei-Che…[et al.]. 2014. The Association between Autoantibodies and Peripheral Neuropathy in Lupus Nephritis. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-478589
Modern Language Association (MLA)
Su, Yu-Jih…[et al.]. The Association between Autoantibodies and Peripheral Neuropathy in Lupus Nephritis. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-478589
American Medical Association (AMA)
Su, Yu-Jih& Huang, Chi-Ren& Chang, Wen-Neng& Tsai, Nai-Wen& Kung, Chia-Te& Lin, Wei-Che…[et al.]. The Association between Autoantibodies and Peripheral Neuropathy in Lupus Nephritis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-478589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478589