Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation
Joint Authors
Kovalainen, Miia
Luostarinen, Mira
Finckenberg, Piet
Martonen, Essi
Lecklin, Anne
Mervaala, Eero
Huotari, Anne
Herzig, Karl-Heinz
Tauriainen, Eveliina
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The potential of resveratrol to mimic beneficial effects of calorie restriction (CR) was investigated.
We compared the effects of both CR (70% of ad libitum energy intake) or resveratrol (2 g/kg or 4 g/kg food) on high-fat diet-induced obesity and fatty liver formation in C57Bl/6J mice, and we examined their effects on calorimetry, metabolic performance, and the expressions of inflammatory genes and SIRT proteins.
We found that resveratrol with 4 g/kg dose partially prevented hepatic steatosis and hepatocyte ballooning and induced skeletal muscle SIRT1 and SIRT4 expression while other examined parameter were unaffected by resveratrol.
In contrast, CR provided superior protection against diet-induced obesity and fatty liver formation as compared to resveratrol, and the effects were associated with increased physical activity and ameliorated adipose tissue inflammation.
CR increased expressions of SIRT3 in metabolically important tissues, suggesting that the beneficial effects of CR are mediated, at least in part, via SIRT3-dependent pathways.
American Psychological Association (APA)
Tauriainen, Eveliina& Luostarinen, Mira& Martonen, Essi& Finckenberg, Piet& Kovalainen, Miia& Huotari, Anne…[et al.]. 2011. Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation. Journal of Nutrition and Metabolism،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-478606
Modern Language Association (MLA)
Tauriainen, Eveliina…[et al.]. Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation. Journal of Nutrition and Metabolism No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-478606
American Medical Association (AMA)
Tauriainen, Eveliina& Luostarinen, Mira& Martonen, Essi& Finckenberg, Piet& Kovalainen, Miia& Huotari, Anne…[et al.]. Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation. Journal of Nutrition and Metabolism. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-478606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478606