Blood Biomarkers for Amyotrophic Lateral Sclerosis : Myth or Reality?
Joint Authors
Robelin, Laura
Gonzalez De Aguilar, Jose Luis
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Amyotrophic lateral sclerosis (ALS) is a fatal condition primarily characterized by the selective loss of upper and lower motor neurons.
At present, the diagnosis and monitoring of ALS is based on clinical examination, electrophysiological findings, medical history, and exclusion of confounding disorders.
There is therefore an undeniable need for molecular biomarkers that could give reliable information on the onset and progression of ALS in clinical practice and therapeutic trials.
From a practical point of view, blood offers a series of advantages, including easy handling and multiple testing at a low cost, that make it an ideal source of biomarkers.
In this review, we revisited the findings of many studies that investigated the presence of systemic changes at the molecular and cellular level in patients with ALS.
The results of these studies reflect the diversity in the pathological mechanisms contributing to disease (e.g., excitotoxicity, oxidative stress, neuroinflammation, metabolic dysfunction, and neurodegeneration, among others) and provide relatively successful evidence of the usefulness of a wide-ranging panel of molecules as potential biomarkers.
More studies, hopefully internationally coordinated, would be needed, however, to translate the application of these biomarkers into benefit for patients.
American Psychological Association (APA)
Robelin, Laura& Gonzalez De Aguilar, Jose Luis. 2014. Blood Biomarkers for Amyotrophic Lateral Sclerosis : Myth or Reality?. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-478607
Modern Language Association (MLA)
Robelin, Laura& Gonzalez De Aguilar, Jose Luis. Blood Biomarkers for Amyotrophic Lateral Sclerosis : Myth or Reality?. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-478607
American Medical Association (AMA)
Robelin, Laura& Gonzalez De Aguilar, Jose Luis. Blood Biomarkers for Amyotrophic Lateral Sclerosis : Myth or Reality?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-478607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478607