Gene Expression in Trypanosomatid Parasites
Joint Authors
Vizuet-de-Rueda, Juan C.
Figueroa-Angulo, Elisa Elvira
Manning-Cela, Rebeca G.
Florencio-Martínez, Luis E.
Martínez-Calvillo, Santiago
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-11
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The parasites Leishmania spp., Trypanosoma brucei, and Trypanosoma cruzi are the trypanosomatid protozoa that cause the deadly human diseases leishmaniasis, African sleeping sickness, and Chagas disease, respectively.
These organisms possess unique mechanisms for gene expression such as constitutive polycistronic transcription of protein-coding genes and trans-splicing.
Little is known about either the DNA sequences or the proteins that are involved in the initiation and termination of transcription in trypanosomatids.
In silico analyses of the genome databases of these parasites led to the identification of a small number of proteins involved in gene expression.
However, functional studies have revealed that trypanosomatids have more general transcription factors than originally estimated.
Many posttranslational histone modifications, histone variants, and chromatin modifying enzymes have been identified in trypanosomatids, and recent genome-wide studies showed that epigenetic regulation might play a very important role in gene expression in this group of parasites.
Here, we review and comment on the most recent findings related to transcription initiation and termination in trypanosomatid protozoa.
American Psychological Association (APA)
Martínez-Calvillo, Santiago& Vizuet-de-Rueda, Juan C.& Florencio-Martínez, Luis E.& Manning-Cela, Rebeca G.& Figueroa-Angulo, Elisa Elvira. 2010. Gene Expression in Trypanosomatid Parasites. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-478619
Modern Language Association (MLA)
Martínez-Calvillo, Santiago…[et al.]. Gene Expression in Trypanosomatid Parasites. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-15.
https://search.emarefa.net/detail/BIM-478619
American Medical Association (AMA)
Martínez-Calvillo, Santiago& Vizuet-de-Rueda, Juan C.& Florencio-Martínez, Luis E.& Manning-Cela, Rebeca G.& Figueroa-Angulo, Elisa Elvira. Gene Expression in Trypanosomatid Parasites. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-478619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478619