The Prothrombotic Tendency in Metabolic Syndrome : Focus on the Potential Mechanisms Involved in Impaired Haemostasis and Fibrinolytic Balance
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-19
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
The metabolic syndrome is a clinical disorder characterized by impairment of glucose metabolism, increased arterial blood pressure, and abdominal obesity.
The presence of these clinical features exposes patients to a high risk of atherothrombotic cardiovascular events.
The pathogenesis of atherothrombosis in the metabolic syndrome is multifactorial, requiring a close relationship among the main components of the metabolic syndrome, including insulin resistance, alterations of glycaemic and lipid pattern, haemodynamic impairment, and early appearance of endothelial dysfunction.
Furthermore, haemostatic alterations involving coagulation balance, fibrinolysis, and platelet function play a relevant role both in the progression of the arterial wall damage and in acute vascular events.
The mechanisms linking abdominal obesity with prothrombotic changes in the metabolic syndrome have been identified and partially elucidated on the basis of alterations of each haemostatic variable and defined through the evidence of peculiar dysfunctions in the endocrine activity of adipose tissue responsible of vascular impairment, prothrombotic tendency, and low-grade chronic inflammation.
This paper will focus on the direct role of adipose tissue on prothrombotic tendency in patients affected by metabolic syndrome, with adipocytes being able to produce and/or release cytokines and adipokines which deeply influence haemostatic/fibrinolytic balance, platelet function, and proinflammatory state.
American Psychological Association (APA)
Russo, Isabella. 2012. The Prothrombotic Tendency in Metabolic Syndrome : Focus on the Potential Mechanisms Involved in Impaired Haemostasis and Fibrinolytic Balance. Scientifica،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-478624
Modern Language Association (MLA)
Russo, Isabella. The Prothrombotic Tendency in Metabolic Syndrome : Focus on the Potential Mechanisms Involved in Impaired Haemostasis and Fibrinolytic Balance. Scientifica No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-478624
American Medical Association (AMA)
Russo, Isabella. The Prothrombotic Tendency in Metabolic Syndrome : Focus on the Potential Mechanisms Involved in Impaired Haemostasis and Fibrinolytic Balance. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-478624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478624