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Navigating the Human Metabolome for Biomarker Identification and Design of Pharmaceutical Molecules
Joint Authors
Panagiotou, Gianni
Kouskoumvekaki, Irene
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-28
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Metabolomics is a rapidly evolving discipline that involves the systematic study of endogenous small molecules that characterize the metabolic pathways of biological systems.
The study of metabolism at a global level has the potential to contribute significantly to biomedical research, clinical medical practice, as well as drug discovery.
In this paper, we present the most up-to-date metabolite and metabolic pathway resources, and we summarize the statistical, and machine-learning tools used for the analysis of data from clinical metabolomics.
Through specific applications on cancer, diabetes, neurological and other diseases, we demonstrate how these tools can facilitate diagnosis and identification of potential biomarkers for use within disease diagnosis.
Additionally, we discuss the increasing importance of the integration of metabolomics data in drug discovery.
On a case-study based on the Human Metabolome Database (HMDB) and the Chinese Natural Product Database (CNPD), we demonstrate the close relatedness of the two data sets of compounds, and we further illustrate how structural similarity with human metabolites could assist in the design of novel pharmaceuticals and the elucidation of the molecular mechanisms of medicinal plants.
American Psychological Association (APA)
Kouskoumvekaki, Irene& Panagiotou, Gianni. 2010. Navigating the Human Metabolome for Biomarker Identification and Design of Pharmaceutical Molecules. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-478640
Modern Language Association (MLA)
Kouskoumvekaki, Irene& Panagiotou, Gianni. Navigating the Human Metabolome for Biomarker Identification and Design of Pharmaceutical Molecules. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-19.
https://search.emarefa.net/detail/BIM-478640
American Medical Association (AMA)
Kouskoumvekaki, Irene& Panagiotou, Gianni. Navigating the Human Metabolome for Biomarker Identification and Design of Pharmaceutical Molecules. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-478640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478640