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“One Ring to Bind Them All”—Part I : The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition
Joint Authors
Saettel, Nicolas
Teulade-Fichou, Marie-Paule
Guédin, Aurore
Mergny, Jean-Louis
Granzhan, Anton
Monchaud, David
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-24
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Macrocyclic scaffolds are particularly attractive for designing selective G-quadruplex ligands essentially because, on one hand, they show a poor affinity for the “standard” B-DNA conformation and, on the other hand, they fit nicely with the external G-quartets of quadruplexes.
Stimulated by the pioneering studies on the cationic porphyrin TMPyP4 and the natural product telomestatin, follow-up studies have developed, rapidly leading to a large diversity of macrocyclic structures with remarkable-quadruplex binding properties and biological activities.
In this review we summarize the current state of the art in detailing the three main categories of quadruplex-binding macrocycles described so far (telomestatin-like polyheteroarenes, porphyrins and derivatives, polyammonium cyclophanes), and in addressing both synthetic issues and biological aspects.
American Psychological Association (APA)
Monchaud, David& Granzhan, Anton& Saettel, Nicolas& Guédin, Aurore& Mergny, Jean-Louis& Teulade-Fichou, Marie-Paule. 2010. “One Ring to Bind Them All”—Part I : The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-19.
https://search.emarefa.net/detail/BIM-478661
Modern Language Association (MLA)
Monchaud, David…[et al.]. “One Ring to Bind Them All”—Part I : The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition. Journal of Nucleic Acids No. 2010 (2010), pp.1-19.
https://search.emarefa.net/detail/BIM-478661
American Medical Association (AMA)
Monchaud, David& Granzhan, Anton& Saettel, Nicolas& Guédin, Aurore& Mergny, Jean-Louis& Teulade-Fichou, Marie-Paule. “One Ring to Bind Them All”—Part I : The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-19.
https://search.emarefa.net/detail/BIM-478661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478661