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Targeting Angiogenesis and Tumor Microenvironment in Metastatic Colorectal Cancer : Role of Aflibercept
Joint Authors
Raieta, Katia
Venditti, Michele
Olivieri, Nunzio
Imbriani, Giusy Carmen
Giordano, Guido
Pancione, Massimo
Campidoglio, Serena
Remo, Andrea
Febbraro, Antonio
Parcesepe, Pietro
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In the last decades, we have progressively observed an improvement in therapeutic options for metastatic colorectal cancer (mCRC) treatment with a progressive prolongation of survival.
mCRC prognosis still remains poor with low percentage of 5-year survival.
Targeted agents have improved results obtained with standard chemotherapy.
Angiogenesis plays a crucial role in colorectal cancer growth, proliferation, and metastasization and it has been investigated as a potential target for mCRC treatment.
Accordingly, novel antiangiogenic targeted agents bevacizumab, regorafenib, and aflibercept have been approved for mCRC treatment as the result of several phase III randomized trials.
The development of a tumor permissive microenvironment via the aberrant expression by tumor cells of paracrine factors alters the tumor-stroma interactions inducing an expansion of proangiogenic signals.
Recently, the VELOUR study showed that addition of aflibercept to FOLFIRI regimen as a second-line therapy for mCRC improved significantly OS, PFS, and RR.
This molecule represents a valid second-line therapeutic option and its peculiar ability to interfere with placental growth factor (PlGF)/vascular endothelial growth factor receptor 1 (VEGFR1) axis makes it effective in targeting angiogenesis, inflammatory cells and in overcoming resistances to anti-angiogenic first-line treatment.
Here, we discuss about Aflibercept peculiar ability to interfere with tumor microenvironment and angiogenic pathway.
American Psychological Association (APA)
Giordano, Guido& Febbraro, Antonio& Venditti, Michele& Campidoglio, Serena& Olivieri, Nunzio& Raieta, Katia…[et al.]. 2014. Targeting Angiogenesis and Tumor Microenvironment in Metastatic Colorectal Cancer : Role of Aflibercept. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-478688
Modern Language Association (MLA)
Giordano, Guido…[et al.]. Targeting Angiogenesis and Tumor Microenvironment in Metastatic Colorectal Cancer : Role of Aflibercept. Gastroenterology Research and Practice No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-478688
American Medical Association (AMA)
Giordano, Guido& Febbraro, Antonio& Venditti, Michele& Campidoglio, Serena& Olivieri, Nunzio& Raieta, Katia…[et al.]. Targeting Angiogenesis and Tumor Microenvironment in Metastatic Colorectal Cancer : Role of Aflibercept. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-478688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478688