Malignant Peripheral Nerve Sheath Tumors in Africa : A Clinicopathological Study
Joint Authors
Juma, Paul Irungu
Nthumba, Peter M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Malignant peripheral nerve sheath tumors (MPNSTs) are rare, aggressive soft tissue sarcomas associated with poor prognosis, that most commonly affect patients aged 20 to 50 years, but have also been reported in children.
There is little reported in literature on these tumors in Africa.
Materials and Methods.
A search of the hospital pathology database between 1992 and 2008 revealed 333 nerve sheath tumors, of which 31 were MPNSTs.
Four representative case reports are presented.
Discussion.
MNPSTs have rarely been reported from sub-Saharan Africa; in this study, they constituted 9.3% of all nerve sheath tumors.
The trunk (42%) and limbs (45%) were the most frequently affected anatomical sites.
Late presentation of malignant lesions in this environment is exemplified by the four case presentations patients.
Conclusions.
This report confirms observations from studies on MPNSTs from other environments.
Anatomically centrally located MPNSTs may have a higher incidence in sub-Saharan Africa than in the West.
Because NF1-associated MPNSTs are difficult to diagnose clinically, and because surgery is the only mode of therapy that offers a complete cure, a lifetime follow-up is important, as this would enable diagnosis of early lesions amenable to surgical extirpation.
American Psychological Association (APA)
Nthumba, Peter M.& Juma, Paul Irungu. 2011. Malignant Peripheral Nerve Sheath Tumors in Africa : A Clinicopathological Study. ISRN Surgery،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-478717
Modern Language Association (MLA)
Nthumba, Peter M.& Juma, Paul Irungu. Malignant Peripheral Nerve Sheath Tumors in Africa : A Clinicopathological Study. ISRN Surgery No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-478717
American Medical Association (AMA)
Nthumba, Peter M.& Juma, Paul Irungu. Malignant Peripheral Nerve Sheath Tumors in Africa : A Clinicopathological Study. ISRN Surgery. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-478717
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478717