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High-Flux Hemodialysis and Levocarnitine in the Treatment of Severe Valproic Acid Intoxication
Joint Authors
Temel, G.
Temel, Volkan
Arıkan, Müge
Source
International Journal of Family Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-21
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Valproic acid (VPA) intoxication incidence is increasing, because of the use of VPA in psychiatric disorders.
The most common finding of VPA intoxication is central nervous system depression which leads to coma and respiratory depression.
Pancreatitis, hyperammonemia, metabolic, and bone marrow failure (thrombocytopenia and leukopenia) have also been described.
Treatment is mainly supportive.
We present the case of an 18-year-old female patient, who made an attempt to autolysis with VPA.
Our patient's VPA plasma level was very high (924 μg/mL), confirming that it was a severe intoxication.
Our treatment including levocarnitine (50 mg/kg per day for 3 days), and high-flux hemodialysis was performed for four hours.
The patient's hemodynamic status and mental function improved in conjunction with the acute reduction in VPA concentrations.
Her subsequent hospital course was complicated by transient thrombocytopenia and levocarnitine induced hypophosphatemia.
By day 6, the patient's laboratory values had completely normalized, and she was transferred to an inpatient psychiatric facility for continuing therapy.
American Psychological Association (APA)
Temel, Volkan& Arıkan, Müge& Temel, G.. 2013. High-Flux Hemodialysis and Levocarnitine in the Treatment of Severe Valproic Acid Intoxication. International Journal of Family Medicine،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-478719
Modern Language Association (MLA)
Temel, Volkan…[et al.]. High-Flux Hemodialysis and Levocarnitine in the Treatment of Severe Valproic Acid Intoxication. International Journal of Family Medicine No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-478719
American Medical Association (AMA)
Temel, Volkan& Arıkan, Müge& Temel, G.. High-Flux Hemodialysis and Levocarnitine in the Treatment of Severe Valproic Acid Intoxication. International Journal of Family Medicine. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-478719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478719