P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD Patients
Joint Authors
Lin, Cheng-Jui
Pan, Chi-Feng
Sun, Fang-Ju
Chen, Han-Hsiang
Wang, Duen-Jen
Liu, Hsuan-Liang
Chuang, Chih-Kuang
Wu, Chih-Jen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background/Aims.
Previous studies have reported p-cresyl sulfate (PCS) was related to endothelial dysfunction and adverse clinical effect.
We investigate the adverse effects of PCS on clinical outcomes in a chronic kidney disease (CKD) cohort study.
Methods.
72 predialysis patients were enrolled from a single medical center.
Serum biochemistry data and PCS were measured.
The clinical outcomes including cardiovascular event, all-cause mortality, and dialysis event were recorded during a 3-year follow-up.
Results.
After adjusting other independent variables, multivariate Cox regression analysis showed age (HR: 1.12, P=0.01), cardiovascular disease history (HR: 6.28, P=0.02), and PCS (HR: 1.12, P=0.02) were independently associated with cardiovascular event; age (HR: 0.91, P<0.01), serum albumin (HR: 0.03, P<0.01), and PCS level (HR: 1.17, P<0.01) reached significant correlation with dialysis event.
Kaplan-Meier analysis revealed that patients with higher serum p-cresyl sulfate (>6 mg/L) were significantly associated with cardiovascular and dialysis event (log rank P=0.03, log rank P<0.01, resp.).
Conclusion.
Our study shows serum PCS could be a valuable marker in predicting cardiovascular event and renal function progression in CKD patients without dialysis.
American Psychological Association (APA)
Lin, Cheng-Jui& Pan, Chi-Feng& Chuang, Chih-Kuang& Sun, Fang-Ju& Wang, Duen-Jen& Chen, Han-Hsiang…[et al.]. 2014. P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-478740
Modern Language Association (MLA)
Lin, Cheng-Jui…[et al.]. P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD Patients. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-478740
American Medical Association (AMA)
Lin, Cheng-Jui& Pan, Chi-Feng& Chuang, Chih-Kuang& Sun, Fang-Ju& Wang, Duen-Jen& Chen, Han-Hsiang…[et al.]. P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-478740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478740