Influence of Polymorphism on Glycosylation of Serum Amyloid A4 Protein
Joint Authors
Yamada, Toshiyuki
Tanaka, Masafumi
Kotani, Kazuhiko
Sato, Jyunji
Source
Biochemistry Research International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Serum amyloid A4 (SAA4) is a constitutive apolipoprotein of high-density lipoprotein.
It exhibits N-linked glycosylation in its second half.
There are both glycosylated and nonglycosylated forms in plasma and the ratio of these two forms varies among individuals.
This study was conducted to examine the influence of genetic polymorphism of SAA4 on its glycosylation status.
In 55 healthy subjects, SAA4 polymorphism was analyzed by PCR combined direct sequencing and its glycosylation status was analyzed by immunoblotting.
The results showed that the percentage of glycosylation in subjects with amino acid substitutions at positions 71 and/or 84 was significantly (P<0.05) higher than that in subjects with the wild type.
The polymorphism had no influence on the plasma concentration of SAA4.
These findings suggest that the changes in protein structures alter the efficiency of glycosylation in the SAA4 molecule.
The functional implication of this should be of interest.
American Psychological Association (APA)
Yamada, Toshiyuki& Sato, Jyunji& Kotani, Kazuhiko& Tanaka, Masafumi. 2014. Influence of Polymorphism on Glycosylation of Serum Amyloid A4 Protein. Biochemistry Research International،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-478775
Modern Language Association (MLA)
Yamada, Toshiyuki…[et al.]. Influence of Polymorphism on Glycosylation of Serum Amyloid A4 Protein. Biochemistry Research International No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-478775
American Medical Association (AMA)
Yamada, Toshiyuki& Sato, Jyunji& Kotani, Kazuhiko& Tanaka, Masafumi. Influence of Polymorphism on Glycosylation of Serum Amyloid A4 Protein. Biochemistry Research International. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-478775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478775