Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical Trials
Joint Authors
Kowalski, Jeanne
Chen, Zhengjia
Cui, Ye
Zhao, Yichuan
Source
Journal of Probability and Statistics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-14
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
The clinical trial, a prospective study to evaluate the effect of interventions in humans under prespecified conditions, is a standard and integral part of modern medicine.
Many adaptive and sequential approaches have been proposed for use in clinical trials to allow adaptations or modifications to aspects of a trial after its initiation without undermining the validity and integrity of the trial.
The application of adaptive and sequential methods in clinical trials has significantly improved the flexibility, efficiency, therapeutic effect, and validity of trials.
To further advance the performance of clinical trials and convey the progress of research on adaptive and sequential methods in clinical trial design, we review significant research that has explored novel adaptive and sequential approaches and their applications in Phase I, II, and III clinical trials and discuss future directions in this field of research.
American Psychological Association (APA)
Chen, Zhengjia& Zhao, Yichuan& Cui, Ye& Kowalski, Jeanne. 2012. Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical Trials. Journal of Probability and Statistics،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-478788
Modern Language Association (MLA)
Chen, Zhengjia…[et al.]. Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical Trials. Journal of Probability and Statistics No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-478788
American Medical Association (AMA)
Chen, Zhengjia& Zhao, Yichuan& Cui, Ye& Kowalski, Jeanne. Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical Trials. Journal of Probability and Statistics. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-478788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478788