Design of an Implantable Device for Ocular Drug Delivery
Joint Authors
Lee, Jae-Hwan
Moorthy, Ramana S.
Pidaparti, Ramana M.
Atkinson, Gary M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ocular diseases, such as, glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, and retinitis pigmentosa require drug management in order to prevent blindness and affecting million of adults in USA and worldwide.
There is an increasing need to develop devices for drug delivery to address ocular diseases.
This study focuses on the design, simulation, and development of an implantable ocular drug delivery device consisting of micro-/nanochannels embedded between top and bottom covers with a drug reservoir made from polydimethylsiloxane (PDMS) which is silicon-based organic and biodegradable polymer.
Several simulations were carried out with six different micro-channel configurations in order to see the feasibility for ocular drug delivery applications.
Based on the results obtained, channel design of osmotic I and osmotic II satisfied the diffusion rates required for ocular drug delivery.
Finally, a prototype illustrating the three components of the drug delivery design is presented.
In the future, the device will be tested for its functionality and diffusion characteristics.
American Psychological Association (APA)
Lee, Jae-Hwan& Pidaparti, Ramana M.& Atkinson, Gary M.& Moorthy, Ramana S.. 2012. Design of an Implantable Device for Ocular Drug Delivery. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-478806
Modern Language Association (MLA)
Lee, Jae-Hwan…[et al.]. Design of an Implantable Device for Ocular Drug Delivery. Journal of Drug Delivery No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-478806
American Medical Association (AMA)
Lee, Jae-Hwan& Pidaparti, Ramana M.& Atkinson, Gary M.& Moorthy, Ramana S.. Design of an Implantable Device for Ocular Drug Delivery. Journal of Drug Delivery. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-478806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478806