The rs1014290 Polymorphism of the SLC2A9 Gene Is Associated with Type 2 Diabetes Mellitus in Han Chinese
Joint Authors
Lin, Ming-Yen
Hwang, Shang-Jyh
Hung, Chi-Chih
Chen, Szu-Chia
Tsai, Jer-Chia
Chang, Jer-Ming
Hwang, Daw-Yang
Liu, Wan-Chun
Chen, Hung-Chun
Chen, Ling-I
Source
Experimental Diabetes Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aims.
The SLC2A9 gene encodes the glucose transporter 9, with the abilities of transporting both glucose and uric acid and is involved in the pancreatic glucose-stimulated insulin secretion.
The single nucleotide polymorphisms (SNPs) of SLC2A9 accounted for 5% variance of serum uric acid (UA).
UA was identified as a risk factor for type 2 diabetes mellitus (DM).
We investigated whether the SLC2A9 gene variations are associated with type 2 DM in Han Chinese.
Methods.
Three common SNPs of the SLC2A9, rs1014290, rs2280205, and rs3733591, were genotyped in 1003 Han Chinese randomly selected from Kaohsiung, Taiwan.
Results.
The variant SNP rs1014290 is associated with decreased 0.12-fold risk of type 2 DM (P=.002).
Per-copy increase in the minor C-allele results in 0.13 mmol/L (P=.037) and 10.03 μmol/L (P=.016) decrease in serum glucose and UA, respectively.
Conclusions.
The SNP rs1014290 within the SLC2A9 gene is associated with type 2 DM in Han Chinese.
American Psychological Association (APA)
Liu, Wan-Chun& Hung, Chi-Chih& Chen, Szu-Chia& Lin, Ming-Yen& Chen, Ling-I& Hwang, Daw-Yang…[et al.]. 2011. The rs1014290 Polymorphism of the SLC2A9 Gene Is Associated with Type 2 Diabetes Mellitus in Han Chinese. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-478808
Modern Language Association (MLA)
Liu, Wan-Chun…[et al.]. The rs1014290 Polymorphism of the SLC2A9 Gene Is Associated with Type 2 Diabetes Mellitus in Han Chinese. Experimental Diabetes Research No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-478808
American Medical Association (AMA)
Liu, Wan-Chun& Hung, Chi-Chih& Chen, Szu-Chia& Lin, Ming-Yen& Chen, Ling-I& Hwang, Daw-Yang…[et al.]. The rs1014290 Polymorphism of the SLC2A9 Gene Is Associated with Type 2 Diabetes Mellitus in Han Chinese. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-478808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478808
