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Altered GABA Signaling in Early Life Epilepsies
Joint Authors
Galanopoulou, Aristea S.
Briggs, Stephen W.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-31
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The incidence of seizures is particularly high in the early ages of life.
The immaturity of inhibitory systems, such as GABA, during normal brain development and its further dysregulation under pathological conditions that predispose to seizures have been speculated to play a major role in facilitating seizures.
Seizures can further impair or disrupt GABAA signaling by reshuffling the subunit composition of its receptors or causing aberrant reappearance of depolarizing or hyperpolarizing GABAA receptor currents.
Such effects may not result in epileptogenesis as frequently as they do in adults.
Given the central role of GABAA signaling in brain function and development, perturbation of its physiological role may interfere with neuronal morphology, differentiation, and connectivity, manifesting as cognitive or neurodevelopmental deficits.
The current GABAergic antiepileptic drugs, while often effective for adults, are not always capable of stopping seizures and preventing their sequelae in neonates.
Recent studies have explored the therapeutic potential of chloride cotransporter inhibitors, such as bumetanide, as adjunctive therapies of neonatal seizures.
However, more needs to be known so as to develop therapies capable of stopping seizures while preserving the age- and sex-appropriate development of the brain.
American Psychological Association (APA)
Briggs, Stephen W.& Galanopoulou, Aristea S.. 2011. Altered GABA Signaling in Early Life Epilepsies. Neural Plasticity،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-478819
Modern Language Association (MLA)
Briggs, Stephen W.& Galanopoulou, Aristea S.. Altered GABA Signaling in Early Life Epilepsies. Neural Plasticity No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-478819
American Medical Association (AMA)
Briggs, Stephen W.& Galanopoulou, Aristea S.. Altered GABA Signaling in Early Life Epilepsies. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-478819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478819