Treatment of Rheumatoid Arthritis with Traditional Chinese Medicine
Joint Authors
Lee, Wen-Yuan
Chen, Calvin Yu-Chian
Chen, Calvin Yu-Chian
Chen, Kuan-Chung
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a chronic inflammatory disease that will affect quality of life and, working efficiency, and produce negative thoughts for patients.
Current therapy of RA is treated with disease-modifying antirheumatic drugs (DMARDs).
Although most of these treatment methods are effective, most patients still have a pleasant experience either due to poor efficacy or side effects or both.
Interleukin-6 receptor (IL6R) is important in the pathogenesis of RA.
In this study, we would like to detect the potential candidates which inhibit IL6R against RA from traditional Chinese medicine (TCM).
We use TCM compounds from the TCM Database@Taiwan for virtually screening the potential IL6R inhibitors.
The TCM candidate compound, calycosin, has potent binding affinity with IL6R protein.
The molecular dynamics simulation was employed to validate the stability of interaction in the protein complex with calycosin.
The analysis indicates that protein complex with calycosin is more stable.
In addition, calycosin is known to be one of the components of Angelica sinensis, which has been indicated to have an important role in the treatment of rheumatoid arthritis.
Therefore, calycosin is a potential candidate as lead compounds for further study in drug development process with IL6R protein against rheumatoid arthritis.
American Psychological Association (APA)
Lee, Wen-Yuan& Chen, Calvin Yu-Chian& Chen, Kuan-Chung& Chen, Calvin Yu-Chian. 2014. Treatment of Rheumatoid Arthritis with Traditional Chinese Medicine. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-478847
Modern Language Association (MLA)
Lee, Wen-Yuan…[et al.]. Treatment of Rheumatoid Arthritis with Traditional Chinese Medicine. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-478847
American Medical Association (AMA)
Lee, Wen-Yuan& Chen, Calvin Yu-Chian& Chen, Kuan-Chung& Chen, Calvin Yu-Chian. Treatment of Rheumatoid Arthritis with Traditional Chinese Medicine. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-478847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478847