Disease Activity in Psoriatic Arthritis : Comparison of the Discriminative Capacity and Construct Validity of Six Composite Indices in a Real World
Joint Authors
Ciapetti, Alessandro
Carotti, Marina
Gutierrez, Marwin
Gasparini, Stefania
Salaffi, Fausto
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
To compare, “in a real world,” the performance of the most common composite activity indices in a cohort of PsA patients.
Methods.
A total of 171 PsA patients were involved.
The following variables were evaluated: peripheral joint assessment, patient reported of pain, physician and patient assessments of disease activity, patient general health status, dactylitis digit count, Leeds Enthesitis Index, Health Assessment Questionnaire (HAQ), physical and mental component summary score of the Medical Outcome Survey (SF-36), Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR).
To measure the disease activity, the Disease Activity Score (DAS28-ESR and DAS28-CRP), Simple Disease Activity Index (SDAI), Composite Psoriatic Disease Activity Index (CPDAI), disease activity in psoriatic arthritis (DAPSA), and Psoriatic Arthritis Disease Activity Score (PASDAS) have been calculated.
The criteria for minimal disease activity (MDA) and remission were applied as external criterion.
Results.
The ROC were similar in all the composite measures.
Only the CPDAI showed less discriminative ability.
There was a high degree of correlation between all the indices (P<0.0001).
The highest correlations were between DAPSA and SDAI (rho = 0.996) and between DAPSA and DAS28-CRP (rho = 0.957).
CPDAI, DAPSA, and PASDAS had the most stringent definitions of remission and MDA category.
DAS28-ESR and DAS28-CRP had the highest proportions in remission and MDA.
Conclusions.
Although a good concurrent validity and discriminant capacity of six disease activity indices were observed, the proportions of patients classified in the disease activity levels differed.
In particular, the rate of patients in remission was clearly different among the respective indices.
American Psychological Association (APA)
Salaffi, Fausto& Ciapetti, Alessandro& Carotti, Marina& Gasparini, Stefania& Gutierrez, Marwin. 2014. Disease Activity in Psoriatic Arthritis : Comparison of the Discriminative Capacity and Construct Validity of Six Composite Indices in a Real World. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-478858
Modern Language Association (MLA)
Salaffi, Fausto…[et al.]. Disease Activity in Psoriatic Arthritis : Comparison of the Discriminative Capacity and Construct Validity of Six Composite Indices in a Real World. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-478858
American Medical Association (AMA)
Salaffi, Fausto& Ciapetti, Alessandro& Carotti, Marina& Gasparini, Stefania& Gutierrez, Marwin. Disease Activity in Psoriatic Arthritis : Comparison of the Discriminative Capacity and Construct Validity of Six Composite Indices in a Real World. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-478858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478858