The Natural History of Uterine Leiomyomas : Light and Electron Microscopic Studies of Fibroid Phases, Interstitial Ischemia, Inanosis, and Reclamation
Joint Authors
Horton, John
Flake, Gordon P.
Robboy, Stanley J.
Dixon, Darlene
Kissling, Grace E.
Walmer, David
Sutton, Deloris
Wicker, Benita
Moore, Alicia B.
Source
Obstetrics and Gynecology International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-21
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
We propose, and offer evidence to support, the concept that many uterine leiomyomas pursue a self-limited life cycle.
This cycle can be arbitrarily divided on the basis of morphologic assessment of the collagen content into 4 phases: (1) proliferation, (2) proliferation and synthesis of collagen, (3) proliferation, synthesis of collagen, and early senescence, and (4) involution.
Involution occurs as a result of both vascular and interstitial ischemia.
Interstitial ischemia is the consequence of the excessive elaboration of collagen, resulting in reduced microvascular density, increased distance between myocytes and capillaries, nutritional deprivation, and myocyte atrophy.
The end stage of this process is an involuted tumor with a predominance of collagen, little to no proliferative activity, myocyte atrophy, and myocyte cell death.
Since many of the dying cells exhibit light microscopic and ultrastructural features that appear distinct from either necrosis or apoptosis, we refer to this process as inanosis, because it appears that nutritional deprivation, or inanition, is the underlying cause of cell death.
The disposal of myocytes dying by inanosis also differs in that there is no phagocytic reaction, but rather an apparent dissolution of the cell, which might be viewed as a process of reclamation as the molecular contents are reclaimed and recycled.
American Psychological Association (APA)
Flake, Gordon P.& Moore, Alicia B.& Sutton, Deloris& Kissling, Grace E.& Horton, John& Wicker, Benita…[et al.]. 2013. The Natural History of Uterine Leiomyomas : Light and Electron Microscopic Studies of Fibroid Phases, Interstitial Ischemia, Inanosis, and Reclamation. Obstetrics and Gynecology International،Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-478889
Modern Language Association (MLA)
Flake, Gordon P.…[et al.]. The Natural History of Uterine Leiomyomas : Light and Electron Microscopic Studies of Fibroid Phases, Interstitial Ischemia, Inanosis, and Reclamation. Obstetrics and Gynecology International No. 2013 (2013), pp.1-20.
https://search.emarefa.net/detail/BIM-478889
American Medical Association (AMA)
Flake, Gordon P.& Moore, Alicia B.& Sutton, Deloris& Kissling, Grace E.& Horton, John& Wicker, Benita…[et al.]. The Natural History of Uterine Leiomyomas : Light and Electron Microscopic Studies of Fibroid Phases, Interstitial Ischemia, Inanosis, and Reclamation. Obstetrics and Gynecology International. 2013. Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-478889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478889