Meta-Analysis of the Related Nutritional Supplements Dimethyl Sulfoxide and Methylsulfonylmethane in the Treatment of Osteoarthritis of the Knee
Joint Authors
Lewith, George
Brien, Sarah
Prescott, Phil
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Dimethyl sulphoxide and methylsulfonylmethane are two related nutritional supplements used for symptomatic relief of osteoarthritis (OA).
We conducted a meta-analysis to evaluate their efficacy in reducing pain associated with OA.
Randomized or quasi-randomized controlled trials (RCTs), identified by systematic electronic searches, citation tracking and searches of clinical trial registries, assessing these supplements in osteoarthritis of any joint were considered for inclusion.
Meta-analysis, based on difference in mean pain related outcomes between treatment and comparator groups, was carried out based on a random effect model.
Seven potential trials were identified of which three RCTs, two DMSO and one MSM (total N=326 patients) were eligible for inclusion.
All three trials were considered high methodological quality.
A significant degree of heterogeneity (χ2=6.28, P=.043) was revealed.
Two studies demonstrated statistically significant (but not clinically relevant) reduction in pain compared with controls; with one showing no group difference.
The meta-analysis confirmed a non significant reduction of pain on visual analogue scale of 6.34 mm (SE = 3.49, 95% CI, −0.49, 13.17).
The overall effect size of 1.82 was neither statistically nor clinically significant.
Current evidence suggests DMSO and MSM are not clinically effective in the reduction of pain in the treatment of OA.
No definitive conclusions can currently be drawn from the data due to the mixed findings and the use of inadequate dosing periods.
American Psychological Association (APA)
Brien, Sarah& Prescott, Phil& Lewith, George. 2011. Meta-Analysis of the Related Nutritional Supplements Dimethyl Sulfoxide and Methylsulfonylmethane in the Treatment of Osteoarthritis of the Knee. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-478893
Modern Language Association (MLA)
Brien, Sarah…[et al.]. Meta-Analysis of the Related Nutritional Supplements Dimethyl Sulfoxide and Methylsulfonylmethane in the Treatment of Osteoarthritis of the Knee. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-478893
American Medical Association (AMA)
Brien, Sarah& Prescott, Phil& Lewith, George. Meta-Analysis of the Related Nutritional Supplements Dimethyl Sulfoxide and Methylsulfonylmethane in the Treatment of Osteoarthritis of the Knee. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-478893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478893