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Neuronal Models for Studying Tau Pathology
Joint Authors
Lim, Filip
Hernández, Félix
Koechling, Thorsten
Avila, Jesus
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder leading to dementia in the aged human population.
It is characterized by the presence of two main pathological hallmarks in the brain: senile plaques containing β-amyloid peptide and neurofibrillary tangles (NFTs), consisting of fibrillar polymers of abnormally phosphorylated tau protein.
Both of these histological characteristics of the disease have been simulated in genetically modified animals, which today include numerous mouse, fish, worm, and fly models of AD.
The objective of this review is to present some of the main animal models that exist for reproducing symptoms of the disorder and their advantages and shortcomings as suitable models of the pathological processes.
Moreover, we will discuss the results and conclusions which have been drawn from the use of these models so far and their contribution to the development of therapeutic applications for AD.
American Psychological Association (APA)
Koechling, Thorsten& Lim, Filip& Hernández, Félix& Avila, Jesus. 2010. Neuronal Models for Studying Tau Pathology. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-478903
Modern Language Association (MLA)
Koechling, Thorsten…[et al.]. Neuronal Models for Studying Tau Pathology. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-478903
American Medical Association (AMA)
Koechling, Thorsten& Lim, Filip& Hernández, Félix& Avila, Jesus. Neuronal Models for Studying Tau Pathology. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-478903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478903