Analyzing Serum-Stimulated Prostate Cancer Cell Lines After Low-Fat, High-Fiber Diet and Exercise Intervention
Joint Authors
Aronson, William J.
Soliman, Sherry
Barnard, R. James
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Serum from men undergoing a low-fat, high-fiber diet and exercise intervention has previously been shown to decrease growth and increase apoptosis in serum-stimulated, androgen-dependent LNCaP cells associated with a reduction in serum IGF-I.
Here we sought to determine the underlying mechanisms for these anticancer effects.
Again, the intervention slowed growth and increased apoptosis in LNCaP cells; responses that were eliminated when IGF-I was added back to the post-intervention samples.
The p53 protein content was increased and NFκB activation reduced in the post serum-stimulated LNCaP cells.
Similar results were observed when the IGF-I receptor was blocked in the pre-intervention serum.
In androgen-independent PC-3 cells, growth was reduced while none of the other factors were changed by the intervention.
We conclude that diet and exercise intervention might help prevent clinical PCa as well as aid in the treatment of PCa during the early stages of development.
American Psychological Association (APA)
Soliman, Sherry& Aronson, William J.& Barnard, R. James. 2011. Analyzing Serum-Stimulated Prostate Cancer Cell Lines After Low-Fat, High-Fiber Diet and Exercise Intervention. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-478959
Modern Language Association (MLA)
Soliman, Sherry…[et al.]. Analyzing Serum-Stimulated Prostate Cancer Cell Lines After Low-Fat, High-Fiber Diet and Exercise Intervention. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-478959
American Medical Association (AMA)
Soliman, Sherry& Aronson, William J.& Barnard, R. James. Analyzing Serum-Stimulated Prostate Cancer Cell Lines After Low-Fat, High-Fiber Diet and Exercise Intervention. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-478959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478959