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Inflammatory Concepts of Obesity
Joint Authors
Rocha, Viviane Zorzanelli
Folco, Eduardo J.
Source
International Journal of Inflammation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Obesity, long considered a condition characterized by the deposition of inert fat, is now recognized as a chronic and systemic inflammatory disease, where adipose tissue plays a crucial endocrine role through the production of numerous bioactive molecules, collectively known as adipokines.
These molecules regulate carbohydrate and lipid metabolism, immune function and blood coagulability, and may serve as blood markers of cardiometabolic risk.
Local inflammatory loops operate in adipose tissue as a consequence of nutrient overload, and crosstalk among its cellular constituents-adipocytes, endothelial and immune cells-results in the elaboration of inflammatory mediators.
These mediators promote important systemic effects that can result in insulin resistance, dysmetabolism and cardiovascular disease.
The understanding that inflammation plays a critical role in the pathogenesis of obesity-derived disorders has led to therapeutic approaches that target different points of the inflammatory network induced by obesity.
American Psychological Association (APA)
Rocha, Viviane Zorzanelli& Folco, Eduardo J.. 2011. Inflammatory Concepts of Obesity. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-478960
Modern Language Association (MLA)
Rocha, Viviane Zorzanelli& Folco, Eduardo J.. Inflammatory Concepts of Obesity. International Journal of Inflammation No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-478960
American Medical Association (AMA)
Rocha, Viviane Zorzanelli& Folco, Eduardo J.. Inflammatory Concepts of Obesity. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-478960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478960