Pivotal Role of AKAP12 in the Regulation of Cellular Adhesion Dynamics : Control of Cytoskeletal Architecture, Cell Migration, and Mitogenic Signaling
Joint Authors
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cellular dynamics are controlled by key signaling molecules such as cAMP-dependent protein kinase (PKA) and protein kinase C (PKC).
AKAP12/SSeCKS/Gravin (AKAP12) is a scaffold protein for PKA and PKC which controls actin-cytoskeleton reorganization in a spatiotemporal manner.
AKAP12 also acts as a tumor suppressor which regulates cell-cycle progression and inhibits Src-mediated oncogenic signaling and cytoskeletal pathways.
Reexpression of AKAP12 causes cell flattening, reorganization of the actin cytoskeleton, and the production of normalized focal adhesion structures.
Downregulation of AKAP12 induces the formation of thickened, longitudinal stress fibers and the proliferation of adhesion complexes.
AKAP12-null mouse embryonic fibroblasts exhibit hyperactivation of PKC, premature cellular senescence, and defects in cytokinesis, relating to the loss of PKC scaffolding activity by AKAP12.
AKAP12-null mice exhibit increased cell senescence and increased susceptibility to carcinogen-induced oncogenesis.
The paper describes the regulatory and scaffolding functions of AKAP12 and how it regulates cell adhesion, signaling, and oncogenic suppression.
American Psychological Association (APA)
Akakura, Shin& Gelman, Irwin H.. 2012. Pivotal Role of AKAP12 in the Regulation of Cellular Adhesion Dynamics : Control of Cytoskeletal Architecture, Cell Migration, and Mitogenic Signaling. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-478976
Modern Language Association (MLA)
Akakura, Shin& Gelman, Irwin H.. Pivotal Role of AKAP12 in the Regulation of Cellular Adhesion Dynamics : Control of Cytoskeletal Architecture, Cell Migration, and Mitogenic Signaling. Journal of Signal Transduction No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-478976
American Medical Association (AMA)
Akakura, Shin& Gelman, Irwin H.. Pivotal Role of AKAP12 in the Regulation of Cellular Adhesion Dynamics : Control of Cytoskeletal Architecture, Cell Migration, and Mitogenic Signaling. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-478976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478976