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Cardiovascular Events in Cancer Patients Treated with Highly or Moderately Emetogenic Chemotherapy : Results from a Population-Based Study
Joint Authors
Nelson, Jeanenne J.
Vo, Thao T.
Source
Journal of Cancer Epidemiology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Studies on cardiovascular safety in cancer patients treated with highly or moderately emetogenic chemotherapy (HEC or MEC), who may have taken the antiemetic, aprepitant, have been limited to clinical trials and postmarketing spontaneous reports.
Our study explored background rates of cardiovascular disease (CVD) events among HEC- or MEC-treated cancer patients in a population-based setting to contextualize events seen in a new drug development program and to determine at a high level whether rates differed by aprepitant usage.
Medical and pharmacy claims data from the 2005–2007 IMPACT National Benchmark Database were classified into emetogenic chemotherapy categories and CVD outcomes.
Among 5827 HEC/MEC-treated patients, frequencies were highest for hypertension (16–21%) and composites of venous (7–12%) and arterial thromboembolic events (4–7%).
Aprepitant users generally did not experience higher frequencies of events compared to nonusers.
Our study serves as a useful benchmark of background CVD event rates in a population-based setting of cancer patients.
American Psychological Association (APA)
Vo, Thao T.& Nelson, Jeanenne J.. 2012. Cardiovascular Events in Cancer Patients Treated with Highly or Moderately Emetogenic Chemotherapy : Results from a Population-Based Study. Journal of Cancer Epidemiology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-478992
Modern Language Association (MLA)
Vo, Thao T.& Nelson, Jeanenne J.. Cardiovascular Events in Cancer Patients Treated with Highly or Moderately Emetogenic Chemotherapy : Results from a Population-Based Study. Journal of Cancer Epidemiology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-478992
American Medical Association (AMA)
Vo, Thao T.& Nelson, Jeanenne J.. Cardiovascular Events in Cancer Patients Treated with Highly or Moderately Emetogenic Chemotherapy : Results from a Population-Based Study. Journal of Cancer Epidemiology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-478992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478992