Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma : An Underrecognized Aggressive Lymphoma
Joint Authors
Morgan, Elizabeth A.
Nascimento, Alessandra F.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Anaplastic lymphoma kinase-(ALK-) positive large B-cell lymphoma (ALK+ LBCL) is a rare, aggressive tumor characterized by an immunoblastic or plasmablastic morphologic appearance, expression of ALK, CD138, CD45, EMA, and often IgA by immunohistochemistry, and characteristic chromosomal translocations or rearrangements involving the ALK locus.
The morphologic and immunophenotypic overlap of this tumor with other hematologic and nonhematologic malignancies may result in misdiagnosis.
The tumor has been identified in both pediatric and adult populations and demonstrates a male predominance.
Presentation is most often nodal, particularly cervical.
No association with immunocompromise or geographic location has been recognized.
The most common gene rearrangement is between clathrin and ALK (t(2;17)(p23;q23)), resulting in the CLTC-ALK chimeric protein, although other fusions have been described.
Response to conventional chemotherapy is poor.
The recent introduction of the small molecule ALK inhibitor, crizotinib, may provide a potential new therapeutic option for patients with this disease.
American Psychological Association (APA)
Morgan, Elizabeth A.& Nascimento, Alessandra F.. 2012. Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma : An Underrecognized Aggressive Lymphoma. Advances in Hematology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-479011
Modern Language Association (MLA)
Morgan, Elizabeth A.& Nascimento, Alessandra F.. Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma : An Underrecognized Aggressive Lymphoma. Advances in Hematology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-479011
American Medical Association (AMA)
Morgan, Elizabeth A.& Nascimento, Alessandra F.. Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma : An Underrecognized Aggressive Lymphoma. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-479011
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479011