Acute Immobilization Stress Modulate GABA Release from Rat Olfactory Bulb : Involvement of Endocannabinoids—Cannabinoids and Acute Stress Modulate GABA Release
Joint Authors
Jaffé, Erica H.
Delgado, Alejandra
Source
International Journal of Cell Biology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We studied the effects of cannabinoids and acute immobilization stress on the regulation of GABA release in the olfactory bulb.
Glutamate-stimulated 3H-GABA release was measured in superfused slices.
We report that cannabinoids as WIN55, 212-2, methanandamide, and 2-arachidonoylglycerol were able to inhibit glutamate- and KCl-stimulated 3H-GABA release.
This effect was blocked by the CB1 antagonist AM281.
On the other hand, acute stress was able per se to increase endocannabinoid activity.
This effect was evident since the inhibition of stimulated GABA release by acute stress was reversed with AM281 and tetrahydrolipstatin.
Inhibition of the endocannabinoid transport or its catabolism showed reduction of GABA release, antagonized by AM281 in control and stressed animals.
These results point to endocannabinoids as inhibitory modulators of GABA release in the olfactory bulb acting through an autocrine mechanism.
Apparently, stress increases the endocannabinoid system, modulating GABAergic synaptic function in a primary sensory organ.
American Psychological Association (APA)
Delgado, Alejandra& Jaffé, Erica H.. 2011. Acute Immobilization Stress Modulate GABA Release from Rat Olfactory Bulb : Involvement of Endocannabinoids—Cannabinoids and Acute Stress Modulate GABA Release. International Journal of Cell Biology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-479036
Modern Language Association (MLA)
Delgado, Alejandra& Jaffé, Erica H.. Acute Immobilization Stress Modulate GABA Release from Rat Olfactory Bulb : Involvement of Endocannabinoids—Cannabinoids and Acute Stress Modulate GABA Release. International Journal of Cell Biology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-479036
American Medical Association (AMA)
Delgado, Alejandra& Jaffé, Erica H.. Acute Immobilization Stress Modulate GABA Release from Rat Olfactory Bulb : Involvement of Endocannabinoids—Cannabinoids and Acute Stress Modulate GABA Release. International Journal of Cell Biology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-479036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479036