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Adjuvant Perioperative Intraperitoneal Chemotherapy in Locally Advanced Colorectal Carcinoma : Preliminary Results
Joint Authors
Korakianitis, Odysseas
Spiliotis, I. D.
Tentes, Antonios-Apostolos K.
Vaxevanidou, A.
Kyziridis, Dimitrios
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Aims.
Intraperitoneal chemotherapy is a basic tool in the treatment of peritoneal malignancy.
The purpose of the study is to investigate the effect of adjuvant perioperative intraperitoneal chemotherapy in the treatment of locally advanced colorectal cancer.
Patients and Methods.
Patients with T3 and T4 colorectal carcinomas that underwent R0 resection received either hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC group=40 patients) or early postoperative intraperitoneal chemotherapy (EPIC group=67 patients).
The survival, the recurrences and the sites of recurrence were assessed.
Results.
The 3-year survival rate for HIPEC group was 100% and for EPIC group 69% (P=.011).
Nodal infiltration was found to be the single prognostic indicator of survival.
The incidence of recurrence in EPIC group was higher than in HIPEC group (P=.009).
The independent indicators of recurrence were the use of HIPEC and the degree of differentiation (P<.05).
Conclusions.
Intraperitoneal chemotherapy, particularly HIPEC, as an adjuvant in locally advanced colorectal carcinomas appears to improve survival and decrease the incidence of recurrence.
American Psychological Association (APA)
Tentes, Antonios-Apostolos K.& Spiliotis, I. D.& Korakianitis, Odysseas& Vaxevanidou, A.& Kyziridis, Dimitrios. 2011. Adjuvant Perioperative Intraperitoneal Chemotherapy in Locally Advanced Colorectal Carcinoma : Preliminary Results. ISRN Surgery،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-479040
Modern Language Association (MLA)
Tentes, Antonios-Apostolos K.…[et al.]. Adjuvant Perioperative Intraperitoneal Chemotherapy in Locally Advanced Colorectal Carcinoma : Preliminary Results. ISRN Surgery No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-479040
American Medical Association (AMA)
Tentes, Antonios-Apostolos K.& Spiliotis, I. D.& Korakianitis, Odysseas& Vaxevanidou, A.& Kyziridis, Dimitrios. Adjuvant Perioperative Intraperitoneal Chemotherapy in Locally Advanced Colorectal Carcinoma : Preliminary Results. ISRN Surgery. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-479040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479040