Effects of Glycyrrhizic Acid on Peroxisome Proliferator-Activated Receptor Gamma (PPARγ), Lipoprotein Lipase (LPL), Serum Lipid and HOMA-IR in Rats
Joint Authors
Yoke Yin, Chia
So Ha, Ton
Abdul Kadir, Khalid
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Studies on ligand binding potential of glycyrrhizic acid, a potential agonist to PPARγ, displayed encouraging results in amelioration of metabolic syndrome.
The regulation of gene cassettes by PPARγ affects glucose homeostasis, lipid, lipoprotein metabolism and adipogenesis.
This study was performed to determine the effects of GA on total PPARγ and LPL expression levels, lipid parameters and HOMA-IR.
Oral administration of 100 mg/kg GA for 24 hours resulted in an increase in insulin sensitivity with decreases in blood glucose, serum insulin and HOMA-IR.
Improvement in serum lipid parameters was also observed with a decrease in triacylglycerol, total cholesterol and LDL-cholesterol and an elevation in HDL-cholesterol.
GA administration also resulted in up-regulation of total PPARγ and LPL expression levels in the visceral and subcutaneous adipose tissues, abdominal and quadriceps femoris muscles, as well as liver and kidney, with a significant up-regulation only in the visceral adipose tissue, abdominal and quadriceps femoris muscles.
Thus, oral administration of 100 mg/kg GA for 24 hours improved insulin sensitivity and lipid profiles and induced upregulation of total PPARγ and LPL expression levels in all studied tissues.
American Psychological Association (APA)
Yoke Yin, Chia& So Ha, Ton& Abdul Kadir, Khalid. 2009. Effects of Glycyrrhizic Acid on Peroxisome Proliferator-Activated Receptor Gamma (PPARγ), Lipoprotein Lipase (LPL), Serum Lipid and HOMA-IR in Rats. PPAR Research،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-479065
Modern Language Association (MLA)
Yoke Yin, Chia…[et al.]. Effects of Glycyrrhizic Acid on Peroxisome Proliferator-Activated Receptor Gamma (PPARγ), Lipoprotein Lipase (LPL), Serum Lipid and HOMA-IR in Rats. PPAR Research No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-479065
American Medical Association (AMA)
Yoke Yin, Chia& So Ha, Ton& Abdul Kadir, Khalid. Effects of Glycyrrhizic Acid on Peroxisome Proliferator-Activated Receptor Gamma (PPARγ), Lipoprotein Lipase (LPL), Serum Lipid and HOMA-IR in Rats. PPAR Research. 2009. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-479065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479065