Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography

Joint Authors

Hartung, Hans-Peter
Brandt, Alexander U.
Young, Kim Lea
Aktas, Orhan
Martin, Roland
Oberwahrenbrock, Timm
Schippling, Sven
Kaufhold, Falko
Keser, Nazmiye
Paul, Friedemann
Zimmermann, Hanna
Harmel, Jens
Ringelstein, Marius

Source

Multiple Sclerosis International

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-07-25

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Background.

Optical coherence tomography (OCT) has facilitated characterisation of retinal alterations in MS patients.

Only scarce and in part conflicting data exists on different MS subtypes.

Objective.

To analyse patterns of retinal changes in different subtypes of MS with latest spectral-domain technology.

Methods.

In a three-centre cross-sectional study 414 MS patients and 94 healthy controls underwent spectral-domain OCT examination.

Results.

Eyes of MS patients without a previous optic neuritis showed a significant reduction of both retinal nerve fibre layer (RNFL) thickness and total macular volume (TMV) compared to healthy controls independent of the MS subtype (P<0.001 for all subtypes).

RNFL thickness was lower in secondary progressive MS (SPMS) eyes compared to relapsing-remitting MS (RRMS) eyes (P=0.007), and TMV was reduced in SPMS and primary progressive MS (PPMS) eyes compared to RRMS eyes (SPMS: P=0.039, PPMS: P=0.005).

Independent of the subtype a more pronounced RNFL thinning and TMV reduction were found in eyes with a previous optic neuritis compared to unaffected eyes.

Conclusion.

Analysis of this large-scale cross-sectional dataset of MS patients studied with spectral-domain OCT confirmed and allows to generalize previous findings.

Furthermore it carves out distinct patterns in different MS subtypes.

American Psychological Association (APA)

Oberwahrenbrock, Timm& Schippling, Sven& Ringelstein, Marius& Kaufhold, Falko& Zimmermann, Hanna& Keser, Nazmiye…[et al.]. 2012. Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography. Multiple Sclerosis International،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-479071

Modern Language Association (MLA)

Oberwahrenbrock, Timm…[et al.]. Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography. Multiple Sclerosis International No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-479071

American Medical Association (AMA)

Oberwahrenbrock, Timm& Schippling, Sven& Ringelstein, Marius& Kaufhold, Falko& Zimmermann, Hanna& Keser, Nazmiye…[et al.]. Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography. Multiple Sclerosis International. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-479071

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-479071