Attenuated Cardiac Mitochondrial-Dependent Apoptotic Effects by Li-Fu Formula in Hamsters Fed with a Hypercholesterol Diet
Joint Authors
Tsai, Fuu-Jen
Chain, Mei-Haung
Hsu, Tsai-Ching
Wu, Chieh-Hsi
Lai, Chao-Hung
Kuo, Wei-Wen
Tsai, Chang-Hai
Tzang, Bor-Show
Wang, Wen-Hong
Huang, Chih-Yang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Apoptosis involves in the pathogenesis of various cardiac abnormalities.
This study intends to evaluate the effects of Li-Fu formula on cardiac apoptosis induced by hyper-cholesterol diet.
Twenty-four male Golden Syrian hamsters were randomly divided into Control, Cholesterol and Li-Fu formula groups.
Histopathological analysis, western blotting and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were performed to measure the effects of Li-Fu formula on left ventricle.
Significantly reduced TUNEL-positive cells and mitochondria- dependent apoptosis were observed in the left ventricle of hamsters from Li-Fu formula group compared to the Cholesterol group.
Additionally, induced cardiac insulin like growth factor I receptor (IGFIR)-dependent survival pathway was detected in the Li-Fu formula group compared to the Cholesterol group.
Besides, minor fibrosis, increased collagen deposition, and myofibril disarray was detected in the Cholesterol group, whereas the reductions of collagen deposition and myofibril disarray were observed in the Li-Fu formula group.
This study demonstrated that Li-Fu formula not only reduced the mitochondria-dependent apoptosis and fibrosis, but also enhanced the IGF-I survival pathway in the left ventricle from high cholesterol-fed hamsters.
We suggest the protective effects of Li-Fu formula on cardiac apoptosis and therapeutic potentials against cardiovascular disease.
American Psychological Association (APA)
Kuo, Wei-Wen& Hsu, Tsai-Ching& Chain, Mei-Haung& Lai, Chao-Hung& Wang, Wen-Hong& Tsai, Fuu-Jen…[et al.]. 2011. Attenuated Cardiac Mitochondrial-Dependent Apoptotic Effects by Li-Fu Formula in Hamsters Fed with a Hypercholesterol Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-479072
Modern Language Association (MLA)
Kuo, Wei-Wen…[et al.]. Attenuated Cardiac Mitochondrial-Dependent Apoptotic Effects by Li-Fu Formula in Hamsters Fed with a Hypercholesterol Diet. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-479072
American Medical Association (AMA)
Kuo, Wei-Wen& Hsu, Tsai-Ching& Chain, Mei-Haung& Lai, Chao-Hung& Wang, Wen-Hong& Tsai, Fuu-Jen…[et al.]. Attenuated Cardiac Mitochondrial-Dependent Apoptotic Effects by Li-Fu Formula in Hamsters Fed with a Hypercholesterol Diet. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-479072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479072