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Circulating Anti-PLAC1 Antibodies during Pregnancy and in Women with Reproductive Failure : A Preliminary Analysis
Joint Authors
Fant, Michael E.
Silva, Celso
Kotto-Kome, Anne C.
Kong, Xiaoyuan
Whiteman, Valerie
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aims of this study were to determine the prevalence of anti-PLAC1 antibodies in normal pregnant women and in women with infertility or recurrent pregnancy loss (RPL).
Secondary outcomes were the development of complications associated with anti-PLAC1 seropositivity and the rate of seroconversion during pregnancy.
Sera from 103 healthy pregnant women and 45 women with unexplained infertility or RPL were analyzed by ELISA.
The prevalence of anti-PLAC1 antibodies was 2% in healthy pregnant women and 4.5% in women with unexplained infertility or RPL (P=0.355).
There was no detectable association of seropositivity with increased risk of pregnancy complications.
Finally, 2% of women seroconverted during pregnancy.
The prevalence of anti-PLAC1 antibodies in women with unexplained infertility or RPL is not significantly higher than the prevalence in normal pregnant women.
However, the sample size in this study was too small.
The exposure to the PLAC1 antigen during pregnancy can lead to the spontaneous development of antibodies.
American Psychological Association (APA)
Kotto-Kome, Anne C.& Silva, Celso& Whiteman, Valerie& Kong, Xiaoyuan& Fant, Michael E.. 2011. Circulating Anti-PLAC1 Antibodies during Pregnancy and in Women with Reproductive Failure : A Preliminary Analysis. ISRN Immunology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-479092
Modern Language Association (MLA)
Kotto-Kome, Anne C.…[et al.]. Circulating Anti-PLAC1 Antibodies during Pregnancy and in Women with Reproductive Failure : A Preliminary Analysis. ISRN Immunology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-479092
American Medical Association (AMA)
Kotto-Kome, Anne C.& Silva, Celso& Whiteman, Valerie& Kong, Xiaoyuan& Fant, Michael E.. Circulating Anti-PLAC1 Antibodies during Pregnancy and in Women with Reproductive Failure : A Preliminary Analysis. ISRN Immunology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-479092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479092