Comparative Study on the MDR Reversal Effects of Selected Chalcones
Joint Authors
Molnar, J.
Serly, J.
Ivanova, A. B.
Stamboliyska, B. A.
Batovska, D. I.
Todorova, I. T.
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Based on the structure of three previously established lead compounds, fifteen selected chalcones were synthesized and evaluated for their multidrug resistance (MDR) reversal activity on mouse lymphoma cells.
The most active chalcones were stronger revertants than the positive control, verapamil.
In the model of combination chemotherapy, the interactions between the anticancer drug doxorubicin and two of the most effective compounds were measured in vitro, on human MDR1 gene transfected mouse lymphoma cells, showing that the type of interaction for one of these compounds was indifferent while that for the other one was additive.
Furthermore, two chalcones inhibited 50% of cell proliferation in concentration of around 0.4 μg/mL and were from 2- to 100-fold more active than the most chalcones.
The structure-activity relationships were obtained and discussed in view of their usefulness for the design of chalcone-like P-gp modulators and drugs able to treat resistant cancers.
American Psychological Association (APA)
Ivanova, A. B.& Batovska, D. I.& Todorova, I. T.& Stamboliyska, B. A.& Serly, J.& Molnar, J.. 2011. Comparative Study on the MDR Reversal Effects of Selected Chalcones. International Journal of Medicinal Chemistry،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479119
Modern Language Association (MLA)
Ivanova, A. B.…[et al.]. Comparative Study on the MDR Reversal Effects of Selected Chalcones. International Journal of Medicinal Chemistry No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-479119
American Medical Association (AMA)
Ivanova, A. B.& Batovska, D. I.& Todorova, I. T.& Stamboliyska, B. A.& Serly, J.& Molnar, J.. Comparative Study on the MDR Reversal Effects of Selected Chalcones. International Journal of Medicinal Chemistry. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479119