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TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition
Joint Authors
Hu, Wensi
Yue, Weiming
Tian, Hui
Li, Lin
Qi, Lei
Gao, Cun
Li, Shuhai
Lu, Ming
Si, Libo
Tian, Yu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In this study, we found that increased BRF2 protein expression was prevalent in NSCLC.
Overexpression of BRF2 correlated with abnormal expression of E-cadherin, N-cadherin, and snail.
Additionally, expression of BRF2 was found to be an independent prognostic factor in NSCLC patients.
Furthermore, we showed that targeted knockdown of BRF2 expression could inhibit the migratory and invasive abilities of NSCLC cells and induced loss of the epithelial-mesenchymal transition of NSCLC cells.
These results suggested that BRF2 overexpression in tumor tissues is significantly associated with the poor prognosis of NSCLC patients through promoting epithelial-mesenchymal transition (EMT) program.
American Psychological Association (APA)
Tian, Yu& Lu, Ming& Yue, Weiming& Li, Lin& Li, Shuhai& Gao, Cun…[et al.]. 2014. TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-479120
Modern Language Association (MLA)
Tian, Yu…[et al.]. TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-479120
American Medical Association (AMA)
Tian, Yu& Lu, Ming& Yue, Weiming& Li, Lin& Li, Shuhai& Gao, Cun…[et al.]. TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-479120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479120