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Impact of Pentoxifylline and Vitamin E on Ribavirin-Induced Haemolytic Anaemia in Chronic Hepatitis C Patients : An Egyptian Survey
Joint Authors
Source
International Journal of Hepatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background/Aim.
We evaluate the impact of combined pentoxifylline and high-dose vitamins E to standard antiviral treatment on RBV-induced haemolytic anaemia.
Patients and Methods.
Selected 200 naïve chronic HCV patients, were randomized to receive either the standard antiviral therapy (peginterferon α-2b and RBV) plus pentoxifylline (800 mg) and high-dose vitamin E (1000 iu) daily (combined group) or received standard antiviral therapy plus placebo only (control group).
They were followed up during treatment course and for 6 months posttreatment to assess the occurrence of anaemia and virological response, respectively.
Results.
RBV dose modification due to anaemia were significantly less in combined group (8.5 versus 21.5%.
P<.05).Withdrawal, secondary to sever anemia (Hb<8.5 gm%), was recorded only in 6 (28.6%) patients of the control group.
Both (ETR) and (SVR) were significantly higher in combined group than control group by both intention-to-treat analysis (71 versus 56%, P<.05 and 66 versus 49%, P<.05) and per-protocol analysis (85.5 versus 70.9%, P<.05 and 79.5 versus 62%, P<.05).
Conclusion.
Pentoxifylline and vitamin E can ameliorate RBV-associated haemolysis; improve compliance and virologic clearance when combined with the standard antiviral therapy in patients with chronic hepatitis C.
American Psychological Association (APA)
Assem, M.& Yousri, M.. 2011. Impact of Pentoxifylline and Vitamin E on Ribavirin-Induced Haemolytic Anaemia in Chronic Hepatitis C Patients : An Egyptian Survey. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479133
Modern Language Association (MLA)
Assem, M.& Yousri, M.. Impact of Pentoxifylline and Vitamin E on Ribavirin-Induced Haemolytic Anaemia in Chronic Hepatitis C Patients : An Egyptian Survey. International Journal of Hepatology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-479133
American Medical Association (AMA)
Assem, M.& Yousri, M.. Impact of Pentoxifylline and Vitamin E on Ribavirin-Induced Haemolytic Anaemia in Chronic Hepatitis C Patients : An Egyptian Survey. International Journal of Hepatology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479133
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479133