Functionally Relevant Residues of Cdr1p : A Multidrug ABC Transporter of Human Pathogenic Candida albicans
Joint Authors
Rawal, Manpreet Kaur
Prasad, Rajendra
Sharma, Monika
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Reduced intracellular accumulation of drugs (due to rapid efflux) mediated by the efflux pump proteins belonging to ABC (ATP Binding Cassette) and MFS (Major Facilitators) superfamily is one of the most common strategies adopted by multidrug resistance (MDR) pathogenic yeasts.
To combat MDR, it is essential to understand the structure and function of these transporters so that inhibitors/modulators to these can be developed.
The sequence alignments of the ABC transporters reveal selective divergence within much conserved domains of Nucleotide-Binding Domains (NBDs) which is unique to all fungal transporters.
Recently, the role of conserved but divergent residues of Candida Drug Resistance 1 (CDR1), an ABC drug transporter of human pathogenic Candida albicans, has been examined with regard to ATP binding and hydrolysis.
In this paper, we focus on some of the recent advances on the relevance of divergent and conserved amino acids of CaCdr1p and also discuss as to how drug interacts with Trans Membrane Domains (TMDs) residues for its extrusion from MDR cells.
American Psychological Association (APA)
Prasad, Rajendra& Sharma, Monika& Rawal, Manpreet Kaur. 2011. Functionally Relevant Residues of Cdr1p : A Multidrug ABC Transporter of Human Pathogenic Candida albicans. Journal of Amino Acids،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-479168
Modern Language Association (MLA)
Prasad, Rajendra…[et al.]. Functionally Relevant Residues of Cdr1p : A Multidrug ABC Transporter of Human Pathogenic Candida albicans. Journal of Amino Acids No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-479168
American Medical Association (AMA)
Prasad, Rajendra& Sharma, Monika& Rawal, Manpreet Kaur. Functionally Relevant Residues of Cdr1p : A Multidrug ABC Transporter of Human Pathogenic Candida albicans. Journal of Amino Acids. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-479168
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479168