Functionally Relevant Residues of Cdr1p : A Multidrug ABC Transporter of Human Pathogenic Candida albicans

Joint Authors

Rawal, Manpreet Kaur
Prasad, Rajendra
Sharma, Monika

Source

Journal of Amino Acids

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-04-27

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Chemistry

Abstract EN

Reduced intracellular accumulation of drugs (due to rapid efflux) mediated by the efflux pump proteins belonging to ABC (ATP Binding Cassette) and MFS (Major Facilitators) superfamily is one of the most common strategies adopted by multidrug resistance (MDR) pathogenic yeasts.

To combat MDR, it is essential to understand the structure and function of these transporters so that inhibitors/modulators to these can be developed.

The sequence alignments of the ABC transporters reveal selective divergence within much conserved domains of Nucleotide-Binding Domains (NBDs) which is unique to all fungal transporters.

Recently, the role of conserved but divergent residues of Candida Drug Resistance 1 (CDR1), an ABC drug transporter of human pathogenic Candida albicans, has been examined with regard to ATP binding and hydrolysis.

In this paper, we focus on some of the recent advances on the relevance of divergent and conserved amino acids of CaCdr1p and also discuss as to how drug interacts with Trans Membrane Domains (TMDs) residues for its extrusion from MDR cells.

American Psychological Association (APA)

Prasad, Rajendra& Sharma, Monika& Rawal, Manpreet Kaur. 2011. Functionally Relevant Residues of Cdr1p : A Multidrug ABC Transporter of Human Pathogenic Candida albicans. Journal of Amino Acids،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-479168

Modern Language Association (MLA)

Prasad, Rajendra…[et al.]. Functionally Relevant Residues of Cdr1p : A Multidrug ABC Transporter of Human Pathogenic Candida albicans. Journal of Amino Acids No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-479168

American Medical Association (AMA)

Prasad, Rajendra& Sharma, Monika& Rawal, Manpreet Kaur. Functionally Relevant Residues of Cdr1p : A Multidrug ABC Transporter of Human Pathogenic Candida albicans. Journal of Amino Acids. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-479168

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-479168