Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats
Joint Authors
Terramorsi, Roxane
Messaoudi, Michaël
Javelot, Hervé
Rougeot, Catherine
Lalonde, Robert
Weiner, Luisa
Source
Depression Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Animal models of anxious disorders found in humans, such as panic disorder and posttraumatic stress disorder, usually include spontaneous and conditioned fear that triggers escape and avoidance behaviors.
The development of a panic disorder model with a learned component should increase knowledge of mechanisms involved in anxiety disorders.
In our ethological model of extreme anxiety in the rat, forced apnea was combined with cold water vaporization in an inescapable situation.
Based on the reactions of vehicle controls, behaviors involved in paroxysmic fear were passive (freezing) and active (jumping) reactions.
Our results show that subchronic fluoxetine (5 mg/kg, IP, 21 days) and imipramine (10 mg/kg, IP, 14 days) administration alleviated freezing and jumping behaviors, whereas acute fluoxetine (1 mg/kg, IP) provoked opposite effects.
Acute low dose of diazepam (1 mg/kg, IP) was not effective, whereas the higher dose of 3 mg/kg, IP, and clonazepam (1 mg/kg, IP) only had an effect on jumping.
Paroxysmic fear generated in this experimental condition may therefore mimic the symptomatology observed in patients with anxiety disorders.
American Psychological Association (APA)
Javelot, Hervé& Weiner, Luisa& Terramorsi, Roxane& Rougeot, Catherine& Lalonde, Robert& Messaoudi, Michaël. 2011. Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats. Depression Research and Treatment،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-479171
Modern Language Association (MLA)
Javelot, Hervé…[et al.]. Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats. Depression Research and Treatment No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-479171
American Medical Association (AMA)
Javelot, Hervé& Weiner, Luisa& Terramorsi, Roxane& Rougeot, Catherine& Lalonde, Robert& Messaoudi, Michaël. Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats. Depression Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-479171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479171