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A Perspective on the Emergence of Sialic Acids as Potent Determinants Affecting Leishmania Biology
Joint Authors
Source
Molecular Biology International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Leishmaniasis caused by Leishmania sp.
has a wide range of manifestations from cutaneous to the deadly visceral form.
They shuttle between the invertebrate and vertebrate hosts as promastigotes and amastigotes having adaptations for subverting host immune responses.
Parasite-specific glycoconjugates have served as important determinants influencing parasite recognition, internalization, differentiation, multiplication, and virulence.
Despite the steady progress in the field of parasite glycobiology, sialobiology has been a less traversed domain of research in leishmaniasis.
The present paper focuses on identification, characterization, and differential distribution of sialoglycotope having the linkage-specific 9-O-acetylated sialic acid in promastigotes of different Leishmania sp.
causing different clinical ramifications emphasizing possible role of these sialoglycotopes in infectivity, virulence, nitric oxide resistance, and host modulation in Leishmania spp.
asserting them to be important molecules influencing parasite biology.
American Psychological Association (APA)
Ghoshal, Angana& Mandal, Chitra. 2011. A Perspective on the Emergence of Sialic Acids as Potent Determinants Affecting Leishmania Biology. Molecular Biology International،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-479229
Modern Language Association (MLA)
Ghoshal, Angana& Mandal, Chitra. A Perspective on the Emergence of Sialic Acids as Potent Determinants Affecting Leishmania Biology. Molecular Biology International No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-479229
American Medical Association (AMA)
Ghoshal, Angana& Mandal, Chitra. A Perspective on the Emergence of Sialic Acids as Potent Determinants Affecting Leishmania Biology. Molecular Biology International. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-479229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479229