Amniotic Membrane as a Scaffold for Melanocyte Transplantation in Patients with Stable Vitiligo
Joint Authors
García-Guzman, María
Marqués, Laura
Andreu, Enrique
Redondo, Pedro
Giménez de Azcarate, Ana
Prósper, Felipe
Source
Dermatology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Vitiligo is an acquired skin disease that significantly impacts the quality of life of patients.
Medical treatment of vitiligo includes the use of melanocyte transplant, but the results are variable.
We have treated 4 patients with either focal or generalized stable vitiligo using a graft of autologous melanocytes' culture on a denuded amniotic membrane (AM).
A culture biopsy was obtained in every patient and grown in melanocytes' media for 10–14 days after which cells were transferred to a denuded AM and transplanted into the achromic lesions.
Patients were followed for up to 6 months using clinical assessment of achromic lesions.
Treated areas ranged between 4 cm2 and 210.6 cm2.
Response to treatment was excellent in all patients with 90–95% repigmentation success rate.
Our results demonstrate that transplantation of autologous melanocytes cultured on AM is a new, simple, and effective treatment for stable vitiligo.
American Psychological Association (APA)
Redondo, Pedro& Giménez de Azcarate, Ana& Marqués, Laura& García-Guzman, María& Andreu, Enrique& Prósper, Felipe. 2011. Amniotic Membrane as a Scaffold for Melanocyte Transplantation in Patients with Stable Vitiligo. Dermatology Research and Practice،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-479232
Modern Language Association (MLA)
Prósper, Felipe…[et al.]. Amniotic Membrane as a Scaffold for Melanocyte Transplantation in Patients with Stable Vitiligo. Dermatology Research and Practice No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-479232
American Medical Association (AMA)
Redondo, Pedro& Giménez de Azcarate, Ana& Marqués, Laura& García-Guzman, María& Andreu, Enrique& Prósper, Felipe. Amniotic Membrane as a Scaffold for Melanocyte Transplantation in Patients with Stable Vitiligo. Dermatology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-479232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479232