Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in Mice
Joint Authors
Hashimoto, Takashi
Kanazawa, Kazuki
Shiomi, Hideyuki
Bouike, Go
Yoshida, Masaru
Nishitani, Yosuke
Azuma, Takeshi
Mizuno, Masashi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
To clarify the mechanism of the antiallergic activity of Agaricus blazei Murill extract (ABME), the present paper used an in vivo allergy model and an in vitro intestinal gut model.
During OVA sensitization, the serum IgE levels decreased significantly in ABME group.
Interleukin (IL)-4 and -5 produced from OVA-restimulated splenocytes was significantly decreased, and anti-CD3ε/CD28 antibody treatment also reduced IL-10, -4, and -5 production and increased IFN-γ production in ABME group.
These results suggest that oral administration of ABME improves Th1/Th2 balance.
Moreover, a coculture system constructed of Caco-2 cells and splenocytes from OT-II mice or RAW 264.7 cells indicated that the significant increases in IFN-γ production by ABME treatment.
Therefore, it was concluded that the antiallergic activity of ABME was due to the activation of macrophages by epithelial cells and the promotion of the differentiation of naïve T cells into Th1 cells in the immune.
American Psychological Association (APA)
Bouike, Go& Nishitani, Yosuke& Shiomi, Hideyuki& Yoshida, Masaru& Azuma, Takeshi& Hashimoto, Takashi…[et al.]. 2010. Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-479240
Modern Language Association (MLA)
Bouike, Go…[et al.]. Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-479240
American Medical Association (AMA)
Bouike, Go& Nishitani, Yosuke& Shiomi, Hideyuki& Yoshida, Masaru& Azuma, Takeshi& Hashimoto, Takashi…[et al.]. Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in Mice. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-479240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479240