Lowering Caveolin-1 Expression in Human Vascular Endothelial Cells Inhibits Signal Transduction in Response to Shear Stress
Joint Authors
van der Meer, A. D.
Feijen, J.
Vermes, I.
Kamphuis, M. M. J.
Poot, A. A.
Source
International Journal of Cell Biology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Vascular endothelial cells have an extensive response to physiological levels of shear stress.
There is evidence that the protein caveolin-1 is involved in the early phase of this response.
In this study, caveolin-1 was downregulated in human endothelial cells by RNAi.
When these cells were subjected to a shear stress of 15 dyn/cm2 for 10 minutes, activation of Akt and ERK1/2 was significantly lower than in control cells.
Moreover, activation of Akt and ERK1/2 in response to vascular endothelial growth factor was significantly lower in cells with low levels of caveolin-1.
However, activation of integrin-mediated signaling during cell adhesion onto fibronectin was not hampered by lowered caveolin-1 levels.
In conclusion, caveolin-1 is an essential component in the response of endothelial cells to shear stress.
Furthermore, the results suggest that the role of caveolin-1 in this process lies in facilitating efficient VEGFR2-mediated signaling.
American Psychological Association (APA)
van der Meer, A. D.& Kamphuis, M. M. J.& Poot, A. A.& Feijen, J.& Vermes, I.. 2008. Lowering Caveolin-1 Expression in Human Vascular Endothelial Cells Inhibits Signal Transduction in Response to Shear Stress. International Journal of Cell Biology،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-479260
Modern Language Association (MLA)
van der Meer, A. D.…[et al.]. Lowering Caveolin-1 Expression in Human Vascular Endothelial Cells Inhibits Signal Transduction in Response to Shear Stress. International Journal of Cell Biology No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-479260
American Medical Association (AMA)
van der Meer, A. D.& Kamphuis, M. M. J.& Poot, A. A.& Feijen, J.& Vermes, I.. Lowering Caveolin-1 Expression in Human Vascular Endothelial Cells Inhibits Signal Transduction in Response to Shear Stress. International Journal of Cell Biology. 2008. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-479260
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479260