Urinary Eosinophil Protein X in Childhood Asthma : Relation with Changes in Disease Control and Eosinophilic Airway Inflammation
Joint Authors
De Jongste, Johan C.
Duiverman, Eric J.
Sterk, Peter J.
Hop, Wim C. J.
Nuijsink, Marianne
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this study was to assess cross-sectional and longitudinal correlations between uEPX and other markers of asthma control and eosinophilic airway inflammation.
Methods.
We measured uEPX at baseline, after 1 year and after 2 years in 205 atopic asthmatic children using inhaled fluticasone.
At the same time points, we assessed symptom scores (2 weeks diary card), lung function (forced expiratory volume in one second (FEV1)), airway hyperresponsiveness (AHR), and percentage eosinophils in induced sputum (% eos).
Results.
We found negative correlations between uEPX and FEV1 at baseline (r=-0.18,P=0.01), after 1 year (r=-0.25,P<0.01) and after 2 years (r=-0.21,P=0.02).
Within-patient changes of uEPX showed a negative association with FEV1 changes (at 1 year: r=-0.24,P=0.01 ; at 2 years: r=-0.21,P=0.03).
Within-patient changes from baseline of uEPX correlated with changes in % eos.
No relations were found between uEPX and symptoms.
Conclusion.
In this population of children with atopic asthma, uEPX correlated with FEV1 and % eos, and within-subjects changes in uEPX correlated with changes in FEV1 and % eos.
As the associations were weak and the scatter of uEPX wide, it seems unlikely that uEPX will be useful as a biomarker for monitoring asthma control in the individual child.
American Psychological Association (APA)
Nuijsink, Marianne& Hop, Wim C. J.& Sterk, Peter J.& Duiverman, Eric J.& De Jongste, Johan C.. 2013. Urinary Eosinophil Protein X in Childhood Asthma : Relation with Changes in Disease Control and Eosinophilic Airway Inflammation. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-479279
Modern Language Association (MLA)
Nuijsink, Marianne…[et al.]. Urinary Eosinophil Protein X in Childhood Asthma : Relation with Changes in Disease Control and Eosinophilic Airway Inflammation. Mediators of Inflammation No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-479279
American Medical Association (AMA)
Nuijsink, Marianne& Hop, Wim C. J.& Sterk, Peter J.& Duiverman, Eric J.& De Jongste, Johan C.. Urinary Eosinophil Protein X in Childhood Asthma : Relation with Changes in Disease Control and Eosinophilic Airway Inflammation. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-479279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479279