The Effect of Alendronate on Proteome of Hepatocellular Carcinoma Cell Lines
Joint Authors
Haneef, Kanwal
Hashim, Zehra
Zarina, Shamshad
Naeem, Nadia
Ilyas, Amber
Source
International Journal of Proteomics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Cancer is a life threatening disorder effecting 11 million people worldwide annually.
Among various types of cancers, Hepatocellular carcinoma (HCC) has a higher rate of mortality and is the fifth leading cause of cancer related deaths around the world.
Many chemotherapeutic drugs have been used for the treatment of HCC with many side effects.
These drugs are inhibitors of different cell regulatory pathways.
Mevalonate (MVA) pathway is an important cellular cascade vital for cell growth.
A variety of inhibitors of MVA pathway have been reported for their anticancerous activity.
Bisphosphonates (BPs) are members of a family involved in the treatment of skeletal complications.
In recent years, their anticancer potential has been highlighted.
Current study focuses on exploring the effects of alendronate (ALN), a nitrogen containing BP, on hepatocellular carcinoma cell line using genomic and proteomics approach.
Our results identified ten differentially expressed proteins, of which five were up regulated and five were down regulated in ALN treated cells.
Furthermore, we also performed gene expression analysis in treated and control cell lines.
The study may help in understanding the molecular mechanism involved in antitumor activity of ALN, identification of possible novel drug targets, and designing new therapeutic strategies for HCC.
American Psychological Association (APA)
Ilyas, Amber& Hashim, Zehra& Naeem, Nadia& Haneef, Kanwal& Zarina, Shamshad. 2014. The Effect of Alendronate on Proteome of Hepatocellular Carcinoma Cell Lines. International Journal of Proteomics،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-479309
Modern Language Association (MLA)
Ilyas, Amber…[et al.]. The Effect of Alendronate on Proteome of Hepatocellular Carcinoma Cell Lines. International Journal of Proteomics No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-479309
American Medical Association (AMA)
Ilyas, Amber& Hashim, Zehra& Naeem, Nadia& Haneef, Kanwal& Zarina, Shamshad. The Effect of Alendronate on Proteome of Hepatocellular Carcinoma Cell Lines. International Journal of Proteomics. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-479309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479309