Pathway-Based Feature Selection Algorithm for Cancer Microarray Data
Joint Authors
Ranka, Sanjay
Kahveci, Tamer
Bandyopadhyay, Nirmalya
Goodison, Steve
Sun, Y.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-03
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Classification of cancers based on gene expressions produces better accuracy when compared to that of the clinical markers.
Feature selection improves the accuracy of these classification algorithms by reducing the chance of overfitting that happens due to large number of features.
We develop a new feature selection method called Biological Pathway-based Feature Selection (BPFS) for microarray data.
Unlike most of the existing methods, our method integrates signaling and gene regulatory pathways with gene expression data to minimize the chance of overfitting of the method and to improve the test accuracy.
Thus, BPFS selects a biologically meaningful feature set that is minimally redundant.
Our experiments on published breast cancer datasets demonstrate that all of the top 20 genes found by our method are associated with cancer.
Furthermore, the classification accuracy of our signature is up to 18% better than that of vant Veers 70 gene signature, and it is up to 8% better accuracy than the best published feature selection method, I-RELIEF.
American Psychological Association (APA)
Bandyopadhyay, Nirmalya& Kahveci, Tamer& Goodison, Steve& Sun, Y.& Ranka, Sanjay. 2010. Pathway-Based Feature Selection Algorithm for Cancer Microarray Data. Advances in Bioinformatics،Vol. 2009, no. 2009, pp.1-16.
https://search.emarefa.net/detail/BIM-479314
Modern Language Association (MLA)
Bandyopadhyay, Nirmalya…[et al.]. Pathway-Based Feature Selection Algorithm for Cancer Microarray Data. Advances in Bioinformatics No. 2009 (2009), pp.1-16.
https://search.emarefa.net/detail/BIM-479314
American Medical Association (AMA)
Bandyopadhyay, Nirmalya& Kahveci, Tamer& Goodison, Steve& Sun, Y.& Ranka, Sanjay. Pathway-Based Feature Selection Algorithm for Cancer Microarray Data. Advances in Bioinformatics. 2010. Vol. 2009, no. 2009, pp.1-16.
https://search.emarefa.net/detail/BIM-479314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479314