The Antiinfective Effects of Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei) on Staphylococcus aureus-Infected Mice
Joint Authors
Chen, Kun-Nan
Chen, Yen-Po
Hong, Wei-Sheng
Dai, Ting-Yeu
Huang, I-Nung
Chen, Ming-Ju
Wang, Chih-Hua
Kuo, Ching-Yun
Wang, Sheng-Yao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We assayed the effects of velvet antler (VA) of Formosan sambar deer (Cervus unicolor swinhoei) and its extracts on the anti-infective activity against pathogenic Staphylococcus aureus in vitro and in vivo in this study.
In vitro data indicated that the VA extracts stimulated the proliferation of resting splenocytes and macrophages in a dose-dependent manner up to the highest concentration used (150 μg mL−1).
The production of proinflammatory cytokines (TNF-α, IL-6, IL-12) by lipoteichoic acid was significantly suppressed after being cocultured with the VA extracts in a dose-dependent manner.
Animal test in S.
aureus-infected mice demonstrated that the numbers of bacteria determined in the kidneys and peritoneal lavage fluid of S.
aureus-infected mice were significantly higher than those found in the same organs of mice pretreated with the VA samples.
Moreover, the highly enhanced phagocytic activity of macrophages was further verified after in vitro treatment with the VA samples.
The protective mechanisms of the VA samples might include an immune enhancer and an inflammatory cytokine suppressor.
American Psychological Association (APA)
Dai, Ting-Yeu& Wang, Chih-Hua& Chen, Kun-Nan& Huang, I-Nung& Hong, Wei-Sheng& Wang, Sheng-Yao…[et al.]. 2011. The Antiinfective Effects of Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei) on Staphylococcus aureus-Infected Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-479321
Modern Language Association (MLA)
Dai, Ting-Yeu…[et al.]. The Antiinfective Effects of Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei) on Staphylococcus aureus-Infected Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-479321
American Medical Association (AMA)
Dai, Ting-Yeu& Wang, Chih-Hua& Chen, Kun-Nan& Huang, I-Nung& Hong, Wei-Sheng& Wang, Sheng-Yao…[et al.]. The Antiinfective Effects of Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei) on Staphylococcus aureus-Infected Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-479321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479321